Abnormalities in puberty : scientific and clinical advances by H.A. Delemarre-van de Waal, P.-E. Mullis

By H.A. Delemarre-van de Waal, P.-E. Mullis

This publication on abnormalities in puberty provides an summary at the most up-to-date wisdom at the mechanisms of the developmental strategies of puberty. even supposing the precise mechanisms of reawakening of the GnRH pulse generator on the onset of puberty nonetheless need to be elucidated, many genetic and environmental components were pointed out to play a tremendous position. subject matters mentioned in person chapters contain the endocrine and metabolic concerns relating to the 'developmental foundation of grownup illness' speculation and polycystic ovary syndrome in addition to abnormalities in GnRH controlling genes, GnRH-secreting hamartoma as a version for the onset of puberty, event at the program of GnRH analogues within the remedy of primary precocious puberty, and the psychosocial results of an early puberty. This quantity offers the paediatrician, endocrinologist, gynaecologist and medical professional with underlying details in addition to sensible tokens on how you can deal with a number of the stipulations of a disturbed means of puberty.

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Ong 36 Animal Studies The first reported association between low birthweight and higher cortisol levels was in female pigs [18]. At the age of 3 or 7 days, low-birthweight female pigs had 70 to 199% higher plasma cortisol levels, higher plasma cortisol binding globulin levels, greater cortisol responses to ACTH, and 46% larger adrenal gland weights (per kg birthweight) than in large birthweight pigs. Similar findings were reported in pigs at age 3 months (pre-pubertal juveniles), and at 12 months (young adults) [19].

Ibanez L, Potau N, Marcos MV, de Zegher F: Exaggerated adrenarche and hyperinsulinism in adolescent girls born small for gestational age. J Clin Endocrinol Metab 1999;84:4739–4741. Hoek A, Schoemaker J, Drexhage HA: Premature ovarian failure and ovarian autoimmunity. Endocr Rev 1997;107–134. Ojeda SR, Andrews WW, Advis JP, Smith White S: Recent advances in the endocrinology of puberty. Endocr Rev 1980;1:228–257. Van der Meer M, Hompes PGA, de Boer JAM, Schats R, Schoemaker J: Cohort size rather than follicle-stimulating hormone threshold level determines ovarian sensitivity in polycystic ovary syndrome.

One smaller study of 52 young men and women found no differences in fasting plasma cortisol levels between low birthweight, premature appropriate birthweight, and full-term normal birthweight groups [24]. A further case control study of low birthweight vs. normal birthweight 12-year-old children found no difference in cortisol levels, despite a clear effect of birthweight on DHEAS levels [25]. The large ALSPAC study also found no association between birthweight and fasting cortisol levels in over 800 children at age 8 years, again despite clear effects of birthweight on adrenal androgen levels [26].

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