Advanced electroporation techniques in biology and medicine by Andrei G. Pakhomov, Damijan Miklavcic, Marko S. Markov

By Andrei G. Pakhomov, Damijan Miklavcic, Marko S. Markov

"A mirrored image of the serious learn of the consequences of electromagnetic fields on residing tissues that has taken position over the last numerous a long time, this ebook discusses the theoretical and experimental proof and issues the results of robust electromagnetic fields and/or electrical pulses and their significance in medication and biology. The authors current the elemental options utilized in electroporation and the complicated equipment for construction of nanopores, highlighting their uncomplicated technology and scientific purposes. themes contain nano electroporation, vintage electroporaiton, experimental facts for electroporation of dwelling cells, and electroporation for melanoma and wound healing"--Provided by means of writer. learn more... content material: fundamentals of Electroporation actual Chemical thought of Membrane Electroporation and Electrotransfer of Biogenic brokers, E. Neumann and S. Kakorin Bioelectric impact of extreme Nanosecond Pulses, K.H. Schoenbach brought on Transmembrane Voltage-Theory, Modeling, and Experiments, T. Kotnik and G. Pucihar Electroporation: A evaluation of simple difficulties in idea and scan, M.S. Markov Mechanisms of Electroporation in Lipid platforms Electrodeformation, Electroporation, and Electrofusion of Cell-Sized Lipid Vesicles, R. Dimova Fluorescent tools in evaluate of Nanopore Conductivity and Their Computational Validation, M. Kotulska, W. Dyrka, and P. Sadowski Electroporation of Lipid Membranes: Insights from Molecular Dynamics Simulations, M. Tarek and L. Delemotte Nanoscale Restructuring of Lipid Bilayers in Nanosecond electrical Fields, P.T. Vernier Mechanisms of Electroporation of Cells Nanopores: a special Transmembrane Passageway in Electroporated Cells, A.G. Pakhomov and O.N. Pakhomova version of mobilephone Membrane Electroporation and Transmembrane Molecular delivery, D. Miklavcic and L. Towhidi Kinetics of Pore Formation and Disappearance within the telephone in the course of Electroporation, G. Saulis the heart beat Intensity-Duration Dependency for phone Membrane Electroporation, D. Miklavcic, G. Pucihar, A.M. Lebar, J. Krmelj, and L. Towhidi Mechanisms of Electroporation in Tissues Drug-Free, reliable Tumor Ablation through Electroporating Pulses: Mechanisms That Couple to Necrotic and Apoptotic mobilephone loss of life Pathways, A.T. Esser, K.C. Smith, T.R. Gowrishankar, and J.C. Weaver Gene Electrotransfer: From simple approaches to Preclinical functions, J.-M. Escoffre, A. Paganin-Gioanni, E. Bellard, M. Golzio, M.-P. Rols, and J. Teissie Technical concerns Modeling electrical box Distribution In Vivo, N. Pavselj, A. Zupanic, and D. Miklavcic innovations of Electroporation Pulse new release and review of electrical Pulse turbines for mobile and Tissue Electroporation, M. Rebersek and D. Miklavcic iteration of Ultrashort Pulses, J.F. Kolb Nanosecond Pulsed electrical box supply to organic Samples: problems and strength strategies, A. Silve, J. Villemejane, V. Joubert, A. Ivorra, and L.M. Mir functions of Electroporation Translation of Electroporation-Mediated DNA supply to the medical institution, L.C. Heller and R. Heller medical Electrochemotherapy: The Italian adventure, C.R. Rossi and L.G. Campana Tumor Blood Flow-Modifying results of Electroporation and Electrochemotherapy-Experimental proof and Implications for the treatment, T. Jarm, M. Cemazar, and G. Sersa lectrochemotherapy as a part of an Immunotherapy process within the remedy of melanoma, J. Gehl ombined electric box and Ultrasound: A Nondrug-Based strategy for Tumor Ablation, P.F. Forde, C. Twomey, G.C. O' Sullivan, and D. M. Soden mixed Modality remedy: Electrochemotherapy with Tumor Irradiation, G. Sersa, S. Kranjc, and M. Cemazar Irreversible Electroporation in medication, B. Rubinsky foodstuff and Biomaterials Processing Assisted via Electroporation, N. Lebovka and E. Vorobiev In Vivo Electroporation: a tremendous damage Mechanism in electric surprise Trauma, I. Barakat, J. Gallaher, H. Chen, and R.C. Lee Index summary: Reflecting the serious examine of the consequences of electromagnetic fields on residing tissues that has taken position through the years, this identify summarizes the experimental findings and theories with regards to permeabilization of biomembranes via pulsed electrical fields. it really is meant generally for biomedical and actual scientists, engineers, and clinicians. learn more...

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Tumor growth depends on the availability of nutrients which, after the disruption of vasculature, requires the formation of new capillaries in a process known as angiogenesis. 16 Survival curve for 17 nsPEF-treated mice and 18 untreated controls with one melanoma each. All 17 treated mice exhibited complete tumor regression without recurrence during the 150 days prior to euthanizing. One of these mice was euthanized on day 130 due to a 20% weight loss in a week but did not exhibit metastasis to the lungs or liver.

14, 1088, 2007. 18 (a) Trypan blue exclusion for B16 cells versus the scaling parameter Eτ N . The number of pulses in the 800 ps experiment was varied between 1 and 20,000, the number in the 10 ns experiment, between 50 and 200. 18a). The results show that trypan blue exclusion is not a dose effect. H. , 2008, IEEE Trans. , 36, 414, 2008. 20) An Eno of 1 for a 10 μm-diameter, spherical cell with Vc = 1 V corresponds to an electric field of 2 kV/cm. 19 versus the normalized pulse duration, with the normalized charge density as a parameter for single pulses (N = 1).

E, 64, 11913-01–11913-03. , 2002, Improved energy model for membrane electroporation in biological cells subjected to electrical pulses, Phys. Rev. E, 65, 041920-01–041920-07. , 2004a, Energy-landscape-model analysis for irreversibility and its pulse-width dependence in cells subjected to a high-intensity ultrashort electrical pulse, Phys. Rev. E, 69, 051901-1–051901-10. , 2004b, Modeling studies of cell response to ultrashort, highintensity electric fields—Implications for intracellular manipulation, IEEE Trans.

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