Advances in Molecular and Cellular Endocrinology, Vol. 2 by Derek LeRoith

By Derek LeRoith

Quantity 2 has excited by elements of the pituitary gland either anterior (growth hormone and prolactin receptors, and GH motion) and posterior (vasopressin) pituitary. furthermore, thyroid melanoma and steroidogenic enzymes and precocious puberty are lined. ultimately, the "hot themes" comprise leptin and development issue signaling.

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Science 255, 306-312. C. (1995). The proline-rich region of the growth hormone receptor is essential for Jak2 phosphorylation, activation of cell proliferation and gene transcription. Mol. Endocrinol. 9, 1701-1707. , & Ailhaud, G. (1989). Growth hormone stimulates c-fos gene expression by means of protein kinase C without increasing inositol lipid turnover. Proc. Natl. Acad. Sci. USA 86, 1148-1152. , & Gibori, G. (1996). Cloning and characterization of an ovarian-specific protein that associates with the short form of the prolactin receptor.

Distinct cytoplasmic regions of the growth hormone receptor are required for activation of JAK2, mitogen-activated protein kinase, and transcription. Endocrinology 135, 1292-1298. , & Finidori, J. (1995). The membrane proximal region of the cytoplasmic domain of the growth hormone receptor is involved in the activation of STAT3. FEBS Lett. 369, 169-172. , & Finidori, J. (1996). Differential activation of STAT3 and STAT5 by distinct regions of the growth hormone receptor. Mol. Endocrinol. 10, 998-1009.

J. Biol. Chem. 271, 12991-12998. K. (1995). Prolactin synthesis and secretion by human breast cancer cells. Cancer Res. 55,2591-2595. A. (1992). Alanine-scanning mutagenesis of human prolactin: importance of the 58-74 region for bioactivity. Mol. Endocrinol. 6, 1381-1392. A. (1994). Evidence for a second receptor binding site on human prolactin. J. Biol. Chem. 269, 32598-32606. L. (1995). Use of a model to understand prolactin and growth hormone specificities. Prot. Eng. 8, 1215-1231. A. (1996a).

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