Animal Models of Human Disease, Volume 100 (Molecular by Min Kyung-Tai, Karen Chang

By Min Kyung-Tai, Karen Chang

Animal experiments have contributed a lot to our figuring out of mechanisms of disorder and are important for settling on new cures. This quantity experiences the newest examine and advancements during this box. * Discusses new discoveries, methods, and ideas * Contributions from prime students and specialists * Reference consultant for researchers occupied with molecular biology and comparable fields

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Interestingly, suppression of Cav-1 expression induces androgen sensitivity in high caveolin, androgen-insensitive mouse prostate cancer cells derived from metastases. 70 Both mouse and human prostate cancer cells secrete Cav-1 that promotes cancer cell survival and clonal growth in vitro. It also promotes proangiogenic activities in prostate cancer through the PI3K–Akt–eNOS signaling module independent of caveolae function. 71 E. The PB-Bcl-2/TRAMP (BxT) Model The antiapoptotic Bcl-2 family includes Bcl-2, Bcl-XL, Bcl-w, Mcl-1, Bfl1/ A-1, and Bcl-B, which bind to and inactivate BH3-domain proapoptotic proteins.

Prostate carcinomas, appearing to arise from PIN lesions, are normally found by 7 months in the VP and 11 months in the DLP. Most adenocarcinomas in the C3(1)/SV40 T mice are locally invasive. The main disadvantage of the C3(1)/ SV40 T model is that the transgene is also expressed in other tissues including MOUSE MODELS OF HUMAN PROSTATE CANCER 15 mammary, thyroid, and salivary glands. Nevertheless, the progression of PIN to invasive prostate carcinoma in the C3(1)/SV40 T mice appears to be similar to the process occurred in humans.

The ampullary glands and vas deferens are extremely cystic, hypertrophic, and hyperplastic; the enlarged epididymi show a reduction of spermatozoa, and the seminal vesicles exhibit a dramatic reduction of seminal secretions. The FGF7 transgenic mice (PKS) that express human FGF7 in the prostatic epithelium driven by the minimal PB promoter develop prostate hyperplasia120; many epithelial ducts are filled with secretory luminal epithelial cells that are tightly associated with highly enfolded basement membranes.

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