By D R Hawkins
Now in its 7th awesome quantity, Biotransformations has turn into demonstrated as a different and critical resource for these concerned about the invention and improvement of recent compounds. It commonly covers the medical literature for the interval 1987 to 1994. The sequence offers a whole survey of the biotransformations, in vertebrates, of the next: prescribed drugs; agrochemicals; meals ingredients; environmental chemical substances; commercial chemical compounds. Biotransformations offers a prepared means of getting access to info at the identified pathways for the biotransformation of structurally-related compounds. Key practical teams supply an index-related technique for retrieving details on compounds of curiosity. yet another index permits the retrieval of examples of particular biochemical reactions which could have wider software. each one quantity corresponds approximately with the medical literature released in the course of a calendar yr. each one quantity features a evaluate bankruptcy which discusses examples of novel biotransformations, species modifications, stereochemical points and mechanisms of toxicity linked to particular biotransformations. learn more... summary: Now in its 7th awesome quantity, Biotransformations has turn into demonstrated as a distinct and critical resource for these keen on the invention and improvement of latest compounds. It extensively covers the medical literature for the interval 1987 to 1994. The sequence offers a whole survey of the biotransformations, in vertebrates, of the next: prescription drugs; agrochemicals; meals ingredients; environmental chemical substances; commercial chemical substances. Biotransformations offers a prepared manner of getting access to details at the recognized pathways for the biotransformation of structurally-related compounds. Key practical teams supply an index-related approach for retrieving details on compounds of curiosity. an additional index permits the retrieval of examples of particular biochemical reactions which can have wider software. every one quantity corresponds approximately with the medical literature released in the course of a calendar 12 months. every one quantity features a assessment bankruptcy which discusses examples of novel biotransformations, species modifications, stereochemical facets and mechanisms of toxicity linked to particular biotransformations
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Additional resources for Biotransformations : a survey of the biotransformations of drugs and chemicals in animals. Vol. 7
59) R =*) N N H H R \ The antiviral agent (62) contains an unusual cyanamide group. Studies with rats and mice showed that most of an oral dose was excreted 8 unchanged in urine (p. 260). The most important urinary metabolite (10-20% of the dose) was the urea (63) resulting from hydrolysis of the cyano group. A polar metabolite was also detected in mouse urine and identified as a mesionic ribose conjugate (64). N I;(HCN N-N (~NHCONH~ N-N w HOCH2 HO OH Microbial and fungal cultures are increasingly being investigated as systems to synthesize potential mammalian metabolites as reference compounds.
S. Von Tungeln, P. P. Fu and K. El-Bayoumy, In vitro and in vivo metabolism of the carcinogen 4-nitropyrene, Chern. Res. , 1994, 7,690. 27 6-Nitrochrysene Useloccurrence: Environmental mutagen Key functional groups: Nitrophenyl, polycyclic aromatic hydrocarbon Test system: Human hepatic and pulmonary microsomes Structure and biotransformation pathway / J I NO2 (1) * =3H 0 Following the incubation of 6-nitrochrysene (1) with human liver or lung microsomes eleven metabolites were detected by HPLC.
178, 179). 5 Conjugates N-Oxidation is a major pathway for the metabolism of pinacidil (50) in several species including man, rat, rabbit, dog and mouse. However, there are some notable species differences in metabolism and also some novel metabolites (p. 274, 275). A unique major conjugated metabolite was detected in rabbit urine only, which was assigned the structure of a glucuronide of the N-hydroxypyridonimine ( 51). This metabolite was formed on incubation of the N-oxide with rabbit liver slices.