By George S. Eisenbarth
Organ particular autoimmune issues as a bunch are liable for an incredible part of all debilitating and every now and then existence threatening power ailments. over the last decade extra has been realized in regards to the molecular pathogenesis of those problems than in the past a hundred years. This contains identity of genes and genetic loci liable for susceptibility, particular molecules whose ingestion or whose endogenous publicity (e.g. oncogenic autoimmunity) set off affliction, cloning of goal autoantigens, identity of molecular pathways of pathogenesis, and discovery fairly in animal versions of antigen particular cures. the present publication brings jointly below an built-in subject, foreign specialists who've contributed to the examine of either particular autoimmune issues and infrequently the examine of a number of organ particular autoimmune ailments.
Both uncomplicated researchers and scientific investigators have contributed to the e-book and the present and destiny impa! ct upon medical care of our bettering knowing of illness pathogenesis is highlighted. the current contains the prognosis and prediction of organ particular autoimmune illnesses with assay established upon cloned goal autoantigens. the longer term will expectantly try our skill to avoid or ameliorate affliction with those comparable molecules. within the research of the a number of illnesses reviewed it truly is was hoping that the various roads will result in an identical vacation spot, particularly molecular disorder prevention and it truly is was hoping that the present e-book may help in achieving this goal.
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Additional resources for Endocrine and Organ Specific Autoimmunity (Molecular Biology Intelligence Unit)
Neuronal proteins and Paraneoplastic Syndromes. N Engl J Med 1989; 321 No. 23:1607-1608. 86. Smith BR, McLachlan SM, Furmaniak J. Autoantibodies to the thyrotropin receptor. Endocr Rev 1988; 9:106-121. 87. Cho BY, Chung JH, Shong YK et al. A strong association between thyrotropin receptorblocking antibody-positive atrophic autoimmune thyroiditis and HLAL-DR8 and HLADQB1*0302 in Koreans. J Clin Endocrinol Metab 1993; 77:611-615. 88. Costagliola S, Swillens S, Niccoli P et al. Binding assay for thyrotropin receptor autoantibodies using the recombinant receptor protein.
J Med Genet 1992; 29:824-826. 6. Tsatsoulis A, Shalet M. Antisperm antibodies in the polyglandular autoimmune (PGA) syndrome type I: Response to cyclical steroid therapy. Clin Endocrinol 1991; 35:299-303. 7. Betterle C, Caretto A, Zeviani M et al. Demonstration and characterization of anti-human mitochondria auto-antibodies in idiopathic hypoparathyroidism and in other conditions. Clin Exp Immunol 1985; 62:353-360. 8. Hung SO, Patterson A. Ectodermal dysplasia associated with autoimmune disease.
66. Davodeau F, Peyrat MA, Necker A et al. Close phenotypic and functional similarities between human and murine alphabeta T cells expressing invariant TCR alpha-chains. J Immunol 1997; 158:5603-5611. 67. Jardetzky TS, Brown JH, Gorga JC et al. Three-dimensional structure of a human class II histocompatibility molecule complexed with superantigen. Nature 1994; 368:711-718. 68. Swaminathan S, Furey W, Pletcher J et al. Crystal structure of staphylococcal enterotoxin B, a superantigen. Nature 1992; 359:801-805.