By Bart C.J.M. Fauser, Andrea R. Genazzani
This quantity bargains an up to date review at the significant components of gynecological endocrinology, providing the newest advances in adolescent gynecological endocrinology, assisted replica, menstrual-related issues, sexuality and transsexualism, polycystic ovary syndrome, myometrial pathology and adenomyosis, weight problems and metabolic syndrome, hormonal birth control, untimely ovarian failure and menopause. In every one bankruptcy the hot advances deriving from easy technology and scientific investigations are with regards to the sensible administration of the situation into consideration, bearing in mind the necessity for individualized remedies. The booklet is released in the ISGE booklet sequence, a three way partnership among the foreign Society of Gynecological Endocrinology and Springer and is predicated at the 2014 foreign college of Gynecological and Reproductive Endocrinology iciness path. it will likely be a tremendous instrument for obstetricians and gynecologists, endocrinologists and specialists in women’s well-being in addition to GPs.
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Additional info for Frontiers in Gynecological Endocrinology: Volume 2: From Basic Science to Clinical Application
Radiologic imaging • Transabdominal US 4 Management of Adolescent Hyperandrogenism 37 The aims of treatment are to regulate menses and improve androgenic concerns as well as lifestyle issues. The treatment is based on the following: • Lifestyle intervention and weight loss, both of which have been found to be beneficial in many areas. • Antiandrogens (cyproterone acetate, Androcur*: 50 mg/day, day 1–day 20) and natural estrogens (Provames*: 2 mg/day, day 1–day 20). • Oral contraceptive pills (OCP), if contraception is needed.
Efficacy and tolerability of a monophasic combined oral contraceptive containing nomegestrol acetate and 17 β-oestradiol in a 24/4 regimen, in comparison to an oral contraceptive containing ethinylestradiol and drospirenone in a 21/7 regimen. Eur J Contracept Reprod Health Care 16(6):430–443 12. Ott ΜΑ, Adler ΝE, Millstein SG, Tschann JM, Ellen JM (2002) The trade-off between hormonal contraceptives and condoms among adolescents. Perspect Sex Reprod Health 34(1):6–14 13. Croxatto HB, Fernandez SD (2006) Emergency contraception – a human rights issue.
Excess or normal 5α-reductase activity in the skin determines the presence or absence of hirsutism . Additionally, estrone plasma levels, a weak estrogen with biological activity 100 times less than estradiol, are increased as a result of the peripheral conversion of androstenedione by aromatase activity, which is more active in PCOS than in healthy controls, while estradiol levels are normal or low because of the frequent anovulatory cycles. All this results in a chronic hyperestrogenic state with the reversal of the estrone:estradiol ratio that may predispose to endometrial proliferation and to a possible increased risk of endometrial cancer [13, 14].