Frontiers in Gynecological Endocrinology: Volume 3: Ovarian by Andrea R. Genazzani, Basil C. Tarlatzis

By Andrea R. Genazzani, Basil C. Tarlatzis

This quantity represents an updated evaluation on ovarian services and copy, supplying the reader with the most recent advances in gynecological endocrinology. It is released in the foreign Society of Gynecological Endocrinology (ISGE) sequence, and relies at the 2015 foreign tuition of Gynecological and Reproductive Endocrinology iciness direction. The publication covers a truly wide variety of topics with specific concentration on ovulation and assisted copy, ovarian getting older and fertility, and untimely ovarian failure. The volume will be an invaluable tool for gynecologists, endocrinologists, obstetrician, and specialists in women’s overall healthiness.

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Additional resources for Frontiers in Gynecological Endocrinology: Volume 3: Ovarian Function and Reproduction - From Needs to Possibilities

Sample text

Huang et al. [16] demonstrated that fractalkine, a chemokine produced at the sites of inflammation and a major regulatory protein for leukocyte recruitment and trafficking expressed in human ovary and luteinizing GC together with CX3CR1, can increase the biosynthesis of progesterone in a dose-dependent manner by enhancing transcript levels of key steroidogenic enzymes but without affecting estradiol (E2) production [16]. CX3CR1 is a seven-transmembranespanning G-protein-coupled receptor expressed on monocytes, natural killer (NK) cells, and some lymphocyte subpopulations and is also expressed in human granulosa cells.

Mol Hum Reprod 7:697–704 16. Balasch J et al (2006) Pretreatment with transdermal testosterone may improve ovarian response to gonadotropins in poor-responder IVF patients with normal basal concentrations of FSH. Hum Reprod 21(7):1884–1893 4 Management of Poor Responders 37 17. Fábregues F et al (2009) Transdermal testosterone may improve ovarian response to gonadotropins in low-responder IVF patients: a randomized, clinical trial. Hum Reprod 24:349–359 18. Gonzalez Comadran M et al (2012) Effects of transdermal testosterone in poor responders undergoing IVF: systematic review and metaanalysis.

These spread to the granulosa cells (GC) where they are transformed to estrogens, by aromatisation, stimulated by the FSH. There is proof of the role of the As as positive regulators of follicular development with synergistic effects with FSH in folliculogenesis. The androgens regulate the function of the GC of the small antral follicles by upregulating the expression of FSH receptors (FSH-R). Treatment with testosterone (T) or dihydrotestosterone (DHT) increases FSH-R expression in the GC in monkey and promises the start of the primordial follicle growth.

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