Greenspan's Basic and Clinical Endocrinology (9th Edition) by David Gardner, Dolores Shoback

By David Gardner, Dolores Shoback

The popular one-stop consultant to the complete box of medical endocrinology and its clinical underpinnings – now in complete color

270+ full-color images and illustrations!

A Doody's center name for 2011!

4 megastar DOODY'S REVIEW!
"This is a superb evaluation of the fundamental body structure and medical facets of endocrinology for trainees. the scale of the e-book and the well-written textual content, supported through visible aids, make this a handy booklet to learn and strengthen a starting origin in endocrinology."--Doody's evaluate Service

Greenspan’s uncomplicated & scientific Endocrinology, 9e can provide a succinct, modern evaluation of the underlying molecular biology of the endocrine procedure and the most recent views at the prognosis and therapy of particular illnesses and issues. that includes an more advantageous layout that incorporates 1000s of full-color illustrations and medical pictures, Greenspan’s is a real must-have in the course of conventional or built-in classes in endocrinology, endocrinology rotation, or for examination prep in inner medication and endocrinology.

Greenspan’s offers clinically correct assurance of metabolic bone ailment, pancreatic hormones and diabetes mellitus, hypoglycemia, weight problems, geriatric endocrinology, and lots of different illnesses and problems. helping this crucial fabric is a convenient appendix of ordinary hormone reference ranges.

Features

*Concise, balanced assurance of either medical and scientific principles

*The top resource for present recommendations in endocrine pathophysiology to help medical choice making

*Important new techniques to the scientific administration of endocrine issues, together with healing recommendations

*The such a lot useful, present insights into diagnostic testing

*More than 270 full-color illustrations and scientific pictures

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Additional resources for Greenspan's Basic and Clinical Endocrinology (9th Edition)

Sample text

This basic region encodes two zinc finger motifs (Figure 1-1 8) that have been shown to establish contacts in the major groove of the cognate DNA recognition ele­ ment (see the discussion later). Based on crystallographic data collected for the DNA-binding region of the GR, we know that the amino acid sequence lying between the first and second fingers (ie, recognition helix) is responsible for establishing specific con­ tacts with the DNA. The second finger provides the stabilizing contacts that increase the affinity of the receptor for DNA.

2006;58:457. [P M I D: 1 69 1 6782] Kiselyov K, Shin OM, Muallem S. Signaling specificity in GPCR-dependent Ca 2+ signaling. Cell Signal. 2003; 1 5 :243. [PMID: 1 253 1 423] Luttrell LM. Transmembrane signaling by G protein-coupled receptors. Methods Mol Bioi. 2006;332:3. [PMID: 1 6878684] Werry TO, Sexton PM, Christopoulos A . " Ins and outs" of seven-transmembrane receptor signaling to ERK. Timd Endocrinol Metab. 2005; 1 6:26. [PM I D: 1 5620546] Woehler A, Ponimaskin EG. G protein-mediated signaling: same receptor, multi­ ple eFFectors.

The second finger provides the stabilizing contacts that increase the affinity of the receptor for DNA. The DNA-binding region also harbors amino acid residues that con­ tribute to the dimerization of monomers contiguously arrayed on the DNA recognition element. Following the basic region is the carboxyl terminal domain of the protein. This domain is respon­ sible for binding of the relevant ligand, receptor dimerization or heterodimerization, and association with the heat shock proteins. It also contributes to the ligand-dependent transactivation func­ tion (incorporated in a subdomain termed AF-2) that drives tran­ scriptional activity.

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