Gynecologic Endocrinology by John G. Gruhn (auth.), Jay J. Gold M.D., F.A.C.P, John B.

By John G. Gruhn (auth.), Jay J. Gold M.D., F.A.C.P, John B. Josimovich M.D. (eds.)

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Netler FN: The CIBA Collection of Medica/Illustrations: Nervous System (Supplement to Vol. I). Summit, NJ, CIBA Pharmaceutical Company, 1957, pp 155-156 3. Adams JH, Daniel PM, Pritchard MD: Transection of the pituitary stalk in man. Anatomical changes in the pituitary gland. J Neurol Neurosurg Psychiatry 29:545-555, 1966 4. Everett JW, Nikitovich-Winer M: Physiology of the pituitary gland as affected by transplantation or stalk section, in Nalbandov, AV (ed): Advances in Neuroendocrinology. Urbana, University of Illinois Press, 1963, pp 289-313* 5.

The fetal neural lobe does contain OT which may initiate labor. Once labor is started, maternal OT is secreted in spurts. As a result, a positive feedback is initiated with uterine contractions, leading to further release of ~T. Antidiuretic Hormone Anterior Pituitary Since ADH is the principal hormone that regulates water diuresis by the kidney, it is logical that the most important regulator of ADH secretion is plasma osmolarity. J J The secretion of ADH increases rapidly with increased plasma osmolarity.

2 Unfortunately, this type of analysis has yet to be applied to other placental hormones. Estriol, human chorionic gonadotropin (hCG) , schwangerschaft protein (SP), as well as hPL, are all secreted in large amounts from the placenta without known feedback-control mechanisms. These hormones either exist in excessive concentrations for their known actions or have no proven physiologic effect. The placenta therefore behaves, in engineering terms, like a free-running system with none of the negative feedback control that characterizes ovarian-pituitary hormone secretion.

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