Melatonin: Biological Basis of Its Function in Health and by S.R. Pandi-Perumal

By S.R. Pandi-Perumal

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Given that a component of the resulting damage is a consequence of free radical mutilation of critical molecules, melatonin’s antioxidant and free radical scavenging activities are assumed to be of paramount importance in limiting I/R-induced tissue damage. , immunomodulatory effects57 as well as potential beneficial effects on mitochondrial oxidative phosphorylation,62 that probably contribute to its protective effects during I/R insults. As summarized herein, pharmacological levels of melatonin were typically given to combat the damage that occurred in the I/R models.

Brain Res 1997; 777:247-250. 12 Melatonin: Biological Basis of Its Function in Health and Disease CHAPTER 2 Oxidative Stress-Mediated Damage during in Vivo Ischemia-Reperfusion Injury: Protective Effects of Melatonin Russel J. Reiter, Rosa M. Sainz, Dun-Xian Tan and Juan C. Mayo Melatonin and Ischemia-Reperfusion Injury Summary T he temporary interruption of blood flow to an organ followed by reperfusion of the tissue with oxygenated blood is highly destructive to the affective cells. While this process, generally referred to as ischemia/reperfusion, can happen in any organ, when this sequence of events occurs in the heart (as a heart attack) or in the brain (as a stroke) the consequences are especially devastating, often leading to death of the individual.

Enhanced protection by melatonin and meloxican combination in a middle cerebral artery occlusion model of acute ischemic stroke in rat. Can J Physiol Pharmacol 2002; 80:210-217. 47. Cho S, Joh TH, Baik HH et al. Melatonin administration protects CA1 hippocampal neurons after transient forebrain ischemia in rats. Brain Res 1997; 755:335-338. 48. Guerrero JM, Reiter RJ, Ortiz GG et al. Melatonin prevents increases in neural nitric oxide and cyclic GMP production after transient brain ischemia and reperfusion in the Mongolian gerbil (Meriones unguiculatus).

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