Modified-Release Drug Delivery Technology by Michael J. Rathbone, Jonathan Hadgraft, Michael S. Roberts,

By Michael J. Rathbone, Jonathan Hadgraft, Michael S. Roberts, Majella E. Lane

InterAG, Hamilton, New Zealand. Reference describes the formula demanding situations and options encountered within the layout, improvement, and commercialization of modified-release drug items for the oral, nasal, ophthalmic, pulmonary, vaginal, dermal, and transdermal pathways.

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Guar gum is a natural product that can vary in specifications crop to crop, season to season. To evaluate the effect of varying lots of guar gum on dissolution, formulation A (Table 1) was manufactured with three lots of guar gum obtained from the same manufacturer. 98). The variability among three commercial sources of guar gum was also evaluated by using formulation A. It was shown that guar gum source did not affect diltiazem release (Table 2). The effect of final powder blend particle size distribution on diltiazem release showed a statistically significant difference in the diltiazem release rate constant as observed from tablets made with 150–600-µm granules compared with those made from 425–600-µm and 250–600-µm granules (Table 2).

Pharmaceutical applications of cyclodextrins. 2. In vivo drug delivery. J Pharm Sci 85:1142–1169, 1996. Copyright © 2003 Marcel Dekker, Inc. 10 Charman and Charman 21. CW Pouton. Formulation of self-emulsifying drug delivery systems. Adv Drug Del Rev 25:47–58, 1997. 22. R Langer, H Chen. Oral particulate delivery: status and future trends. Adv Drug Del Rev 34:339–350, 1998. 23. L Illum. Chitosan and its use as a pharmaceutical excipient. Pharm Res 15:1326– 1331, 1998. 24. GM Pauletti, S Gangwar, TJ Siahaan, J Aube, RT Borchardt.

The release of drug proceeds primarily out of the sides of the tablet as it passes through the intestinal tract. 2 Parameter Copyright © 2003 Marcel Dekker, Inc. Test 30 Altaf and Friend zero-order drug release following a programmed period of delayed drug release. A variety of drug release profiles can be obtained by adjusting the coating thickness and/or the matrix core composition. To achieve a constant zero-order matrix sustained release formulation (COSRx) for a poorly water-soluble drug such as nifedipine (Յ10 µg mLϪ1), a low-molecular-weight guar gum (Tico-LV) was used.

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