Molecular Biology of B Cells by Tasuku Honjo, Visit Amazon's Michael Reth Page, search

By Tasuku Honjo, Visit Amazon's Michael Reth Page, search results, Learn about Author Central, Michael Reth, , Andreas Radbruch, Frederick Alt

Molecular Biology of B Cells, moment Edition is a complete connection with how B cells are generated, chosen, activated and engaged in antibody construction. All of those developmental and stimulatory techniques are defined in molecular, immunological, and genetic phrases to offer a transparent knowing of advanced phenotypes.

Molecular Biology of B Cells, moment Edition bargains an built-in view of all facets of B cells to provide a typical immune reaction as a relentless, and the molecular foundation of various ailments as a result of B phone abnormality. the hot version maintains its good fortune with up-to-date learn on microRNAs in B phone improvement and immunity, new advancements in realizing lymphoma biology, and healing concentrating on of B cells for scientific program. With up-to-date examine and persevered finished assurance of all points of B cellphone biology, Molecular Biology of B Cells, moment Edition is the definitive source, very important for researchers throughout molecular biology, immunology and genetics.

  • Covers signaling mechanisms regulating B phone differentiation
  • Provides details at the improvement of therapeutics utilizing monoclonal antibodies and medical program of Ab
  • Contains reports on B telephone tumors from a number of phases of B lymphocytes
  • Offers an built-in view of all features of B cells to provide a typical immune response

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105] Thomas JO, Travers AA. HMG1 and 2, and related “architectural” DNA-binding proteins. Trends Biochem Sci 2001;26:167–74. [106] Swanson PC. Fine structure and activity of discrete RAG-HMG complexes on V(D)J recombination signals. Mol Cell Biol 2002;22:1340–51. [107] Aidinis V, Bonaldi T, Beltrame M, Santagata S, Bianchi ME, Spanopoulou E. The RAG1 homeodomain recruits HMG1 and HMG2 to facilitate recombination signal sequence binding and to enhance the intrinsic DNA-bending activity of RAG1-RAG2.

J Immunol 2001;167:866–74. [150] Johnson K, Angelin-Duclos C, Park S, Calame KL. Changes in histone acetylation are associated with differences in accessibility of V(H) gene segments to V-DJ recombination during B-cell ontogeny and development. Mol Cell Biol 2003;23:2438–50. [151] Mathieu N, Hempel WM, Spicuglia S, Verthuy C, Ferrier P. Chromatin remodeling by the T cell receptor (TCR)-beta gene enhancer during early T cell development: Implications for the control of TCR-beta locus recombination.

Thus, the accessibility of an entire cluster of antigen receptor gene segments can be regulated at the scale of several hundred kilobases of DNA. Furthermore, it has also been shown that the antigen receptor loci undergo large-scale locus contraction during lymphocyte development [176–178]. This locus contraction, which probably occurs via chromosomal looping [177–179] and seems to be regulated by transcription factors such as Pax5 [180], YY1 [175], Ikaros [181], and CTCF [182], brings recombinationally active gene segments into proximity with one another, thereby facilitating the joining of otherwise distant V, D, and J gene segments.

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