Molecular Genetics of Immunoglobulin by F. Calabi and M.S. Neuberger (Eds.)

By F. Calabi and M.S. Neuberger (Eds.)

Our figuring out of the molecular genetics of immunoglobulins has been greatly complex by means of the appliance of recombinant DNA expertise. This new quantity within the renowned sequence New accomplished Biochemistry comprises 8 chapters that draw jointly reports summarising the learn into immunoglobulins and the association, rearrangement and expression in their gene constitution. Molecular Genetics of Immunoglobulin may be of specific value to these operating within the components of genetics and molecular biology, immunology, and phone biology.

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Molecular Genetics of Immunoglobulin

Our realizing of the molecular genetics of immunoglobulins has been drastically complicated by means of the appliance of recombinant DNA know-how. This new quantity within the well known sequence New accomplished Biochemistry comprises 8 chapters that draw jointly stories summarising the study into immunoglobulins and the association, rearrangement and expression in their gene constitution.

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2. I. Antigen binding Pentameric IgM is decavalent with small antigens as expected but only pentavalent with larger antigens presumably due to steric hindrance [SO]. Electron micrographs of specific sheep IgM bound to Salmonella paratyphi flagellum indicate that interaction with antigen is accompanied b y a considerable conformational change [76,80,41]. It appears that a flexion occurs between the C,2 and C,3 domains to dislocate F(ab’)2 units relative to the central Fc, disc and produce the ‘staple’ form represented in Fig.

The multivalency of both IgG and protein A with respect to one another means that if the two are added to one another in the correct proportions they will form extended complexes and precipitate. 8 A [23] and indicates that protein A binds at a site between C,2 and C,3 domains. This binding is observed for the human IgG subclasses IgG1, IgG2 and IgG4 and also for IgG3 proteins bearing allotypic markers characteristic of Mongoloid populations ( 5 I ] . In IgG3 proteins from Caucasian populations the protein A contact residue His-435 of the above IgGs is replaced by Arg.

Disulphide bridges are believed to be important in the polymerisation of IgM although the nature of the linkages is controversial. One model [76] links the extra cysteine in the C,3 domain (position 309 in the numbering of Table 5 ) to the corresponding cysteine on an adjacent monomer and the penultimate cysteine of the tailpiece again to the corresponding cysteine on an adjacent monomer or to the J chain (the J chain has two cysteine residues). An- 37 C termini Fig. I I . The structure of IgM.

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