By Joseph Hill
''This two-volume set is amazing by means of its emphasis on common muscle functionality in addition to alterations obvious in pathology or ailment. healing interventions finish every one part, however the technology comes first. association of 108 chapters is in sections on cardiac muscle (basic body structure, variations and reaction, myocardial disease); skeletal muscle (basics and diversifications, ailment, and therapeutics); and gentle muscle (physiology, heterogeneities, diversifications and reaction, and disease). Editors Hill and Olson (both: U. of Texas Southwestern clinical heart) have shepherded the paintings of participants based within the US, with a number of from Europe.''-- Reference & study publication NewsOctober 2012
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Additional resources for Muscle. Fundamental Biology and Mechanisms of Disease
In flies, several members of the core network are required individually. As noted earlier in this chapter, the NK class homeodomain protein Cardiac Muscle Tinman is absolutely required for heart development in flies. Similarly, the GATA factor Pannier is required for cardial cell development (67). This is analogous to the acardia phenotype seen in mouse embryos lacking Gata4 and Gata6 function, suggesting a conserved, required role for the GATA family in cardiogenesis. Likewise, loss-offunction mutations in the sole Mef2 gene in Drosophila result specifically in loss of muscle differentiation; the heart forms in Mef2 mutants, but myocardial differentiation is almost completely disrupted (72).
3 Labeling and contribution of the anterior heart field by a Mef2c-enhancer transgene. The first three panels show the dynamic expression of the Mef2cAHF::lacZ reporter, which is active early in the anterior portion of the second heart field, including the right ventricle (RV) outflow tract (OFT). The transgene is also expressed in branchial arches (BA) and pharyngeal mesoderm (PM). The last panel shows the lineage trace of the Mef2cAHF-expressing cells, which populate aortic (ao) and pulmonary artery (pa) myocardium, the right ventricle (rv), and the interventricular septum (dashed red line).
Cai CL, Liang X, Shi Y, Chu PH, Pfaff SL, Chen J, et al. Isl1 identifies a cardiac progenitor population that proliferates prior to differentiation and contributes a majority of cells to the heart. Dev Cell 2003;5:877À89. 44. Franco D, Meilhac SM, Christoffels VM, Kispert A, Buckingham M, Kelly RG. Left and right ventricular contributions to the formation of the interventricular septum in the mouse heart. Dev Biol 2006;294:366À75. 45. Zaffran S, Kelly RG, Meilhac SM, Buckingham ME, Brown NA. Right ventricular myocardium derives from the anterior heart field.