By Bonita Morrow Cavanaugh
Univ. of Colorado, Denver. textual content covers nursing care ahead of, in the course of, and after diagnostic checks. contains heritage info and outlines of universal exams by way of medical purposes with regard values. for college kids and practitioners. past version: c1999. Softcover. DNLM: Laboratory concepts and Procedures--nurses' guide handbooks.
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This variant severely reduces enzymatic activity and leads to more severe hemolytic episodes, which are triggered by a greater variety of stimuli and are less likely to be self-limited than in persons with the type A variant. 32 PYRUVATE KINASE Pyruvate kinase (PK) functions in the formation of pyruvate and adenosine diphosphate (ADP) in glycolysis. The pyruvate thus formed is subsequently converted to lactate. RBCs that lack PK have a low affinity for oxygen. Episodes of hemolysis in individuals lacking this enzyme are severe and chronic and are exacerbated by stressors such as infection.
Davis Company CHAPTER 1—Hematology Figure 1–4. Changes in hemoglobin with development. (From Hillman, RS, and Finch, CA: Red Cell Manual, ed 7. FA Davis, Philadelphia, 1996, p. ) of Hgb that evolves from unpaired ␥ chains. Hemoglobin Barts itself has such a high affinity for oxygen that it releases none to the tissues. In ␤-thalassemia minor, a decrease is seen in ␤chain production and, therefore, a reduction in the amount of Hgb A formed. In ␤-thalassemia major, all ␤-chain production is lost and no Hgb A is formed.
A. Davis Company CHAPTER 1—Hematology Suspected G-6-PD or PK deficiency, especially in individuals with positive family history or with jaundice occurring in response to stressors, oxidant drugs, or foods such as fava beans NURSING CARE BEFORE THE PROCEDURE Client preparation is the same as that for any study involving the collection of a peripheral blood sample (see Appendix I). THE PROCEDURE A venipuncture is performed and the sample collected in a lavender-topped tube. A capillary sample may be collected in infants and children as well as in adults for whom venipuncture may not be feasible.