By John P. Bilezikian MD, Robert Marcus MD, Michael A. Levine
The 3rd version of The Parathyroids, led by way of a brand new stellar editorial workforce, has been completely up-to-date to mirror the huge advances in exactly approximately each point of PTH biology during the last decade. It is still the authoritative reference that spans the elemental technology of parathyroid hormone therapy to significant medical issues in an excellent, unmarried compendium. This translational source is useful to graduate scholars, fellows, researchers, and study clinicians within the fields of endocrinology, bone biology, osteology, and rheumatology.
NEW TO THIS EDITION:
- Contains chapters and data on noninvasive imaging, fracture therapeutic, secondary illnesses comparable to CKD, nutrition D, phone signaling pathways, vascular calcification, in addition to advances in genetics/genomics
- Includes crucial updates at the severe value of diet D insufficiency and its dating to secondary hyperparathyroidism
- Offers new insights into the underlying mechanisms of parathyroid hormone activities on osteocytes and sclerostin
- Examines crucial updates within the realizing of secondary hyperparathyroidism linked to power kidney sickness, facture therapeutic, and vascular disease
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Additional info for Parathyroids : basic and clinical concepts
The initial clinical presentation of parathyroid carcinoma may be that of palpable neck mass, which can be mistaken for a tumor originating in the thyroid. Beside the laboratory studies, ultrasonography, sestamibi scan, computed tomography, and magnetic resonance imaging can be helpful in confirming the clinical diagnosis. , into the surrounding neck structures as well as lymph node metastases. 99,101,104–106 The only curative treatment for parathyroid carcinoma is en bloc surgical resection; however, the success of the surgery is highly dependent on the preoperative diagnosis of this tumor.
Endocrinology 1932;16:547–58. Tsung CM, Fraenkel-Conrat H. Preferential release of aspartic acid by dilute acid treatment of tryptic peptides. Biochemistry 1965;4:793–801. Aurbach GD, Keutmann HT, Niall HD, Tregear JLH, O’Riordan JLH, Marcus R, et al. Structure, synthesis and mechanism of action of parathyroid hormone. Recent Prog Horm Res 1972;28:353–98. Steenbock H, Black A. Fat-soluble vitamins. XXIII. The induction of growth-promoting and calcifying properties in fats and their unsaponifiable constituents by exposure to light.
Chronic response of dogs to parathyroid hormone infusion. Nature 1974;250:254–7. Tam CS, Heersche JN, Murray TM, Parsons JA. Parathyroid hormone stimulates the bone apposition rate independently of its resorptive action: differential effects of intermittent and continuous administration. Endocrinology 1982;110:506–12. Kalu DN, Doyle FH, Pennock J, Denys-Matrajt H, Foster GV. Anabolic effect of parathyroid hormone on bone in the rat. Calcif Tiss Res 1970;(Suppl. 72) (Abstract). Walker DG. The induction of osteopetrotic changes in hypophysectomized, thyroparathyroidectomized, and intact rats of various ages.