The Osteoporosis Primer by Janet E. Henderson, David Goltzman

By Janet E. Henderson, David Goltzman

Osteoporosis is among the top factors of morbidity and mortality one of the aged. the explanation for The Osteoporosis Primer is to supply an introductory textual content that relates the medical presentation of osteoporosis to its molecular biochemical foundation. The textual content has been geared up into 4 sections that take care of the molecular/cellular parts of bone, the advance of height bone mass, the pathophysiology of getting older bone and at last, how all of those relate to the prevention, prognosis, and remedy of osteoporosis. The foreign workforce of authors comprises many prime clinicians and scientists who've supplied the reader with a concise, but accomplished, synopsis of bone improvement and skeletal homeostasis. This booklet might be an important creation for people engaged on osteoporosis, together with scholars and medical professionals contemplating a occupation on the topic of metabolic bone sickness, common practitioners, geriatricians, rheumatologists, and endocrinologists.

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Moritz J. , & von Figura, K. (1998). Impaired osteoclastic bone resorption leads to osteopetrosis in cathepsin-K-deficient mice. Proc. Natl Acad. , USA, 95, 13453–8. , & Ohtsu, H. (1994). Immunolocalization of complement CIs and matrix metalloproteinase 9 (92KDa gelatinase/type IV collagenase) in the primary ossification center of the human femur. , 277, 239–45. , Pearman, A. , Pulumati, M. , & Partridge, N. C. (1998). Parathyroid hormone regulates the rat collagenase-3 promoter in osteoblastic cells through the cooperative interaction of the activator protein-1 site and the runt domain binding sequence.

Mol. , 54, 70–7. , Gupta, A. , Delmas, P. , & Aubin, J. E. (1998). LIF, but not IL-6, regulates osteoprogenitor differentiation: Modulation by dexamethasone. J. Bone Miner. , 13, 175–84. Mullender, M. G. & Huiskes, R. (1997). Osteocytes and bone lining cells: which are the best candidates for mechano-sensors in cancellous bone? Bone, 20, 527–32. Nuttall, M. , Patton, A. , Olivera, D. , Nadeau, D. , & Gowen, M. (1998). Human trabecular bone cells are able to express both osteoblastic and adipocytic phenotype: implications for osteogenic disorders.

1). They are often located in slight ‘indentations’ of the bone surface called Howship’s lacunae, which result from osteoclasts having dissolved a small area of bone underneath the cell. Osteoclasts contain large amounts of the enzyme tartrate-resistant acid phosphatase (TRAP), and when stained histochemically for this enzyme become quite conspicuous. What also becomes apparent in histological sections so stained, however, is that not all osteoclasts contain large 36 37 Osteoclasts Fig. 1 (A) Histological section through mineralized cancellous bone from an iliac crest biopsy of a patient with renal osteodystrophy.

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