Uterine Endometrial Function by Hideharu Kanzaki

By Hideharu Kanzaki

This e-book specializes in uterine endometrial functionality and receptivity from a number of views. The chapters hide numerous issues together with the position of estrogen and progesterone, animal types, parameters for assessing endometrial receptivity, the mechanism of angiogenesis, epigenetic rules, and stem/progenitor cells. regardless of approximately 35 years of expertise with in vitro fertilization, the speed of winning implantations continues to be low. irregular endometrial receptivity has been proposed as one of many components contributing to diminished reproductive strength in ladies, yet our figuring out of it truly is constrained. Endometrial receptivity effects from an orchestrated interaction among the embryo and the maternal endometrium, and the receptive prestige, often called the window of implantation, is reached purely in short within the mid-luteal part. This booklet offers a entire evaluate of the most recent advances in endometrial functionality and paves the best way for leading edge remedies and drug improvement for infertility. This paintings will entice a large readership, from researchers on endometrial functionality and assisted reproductive know-how (ART) to clinicians and technicians within the box of gynecology.

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It does, however, highlight the redundancy of ‘whole tissue’ analysis. An endometrial receptivity array (ERA) [69] is currently undergoing multicentre trials. For this test 238 genes that are differentially regulated within the endometrial cycle are customised on a single array. Of these, 134 genes represent a specific transcriptomic signature of the receptive phase. 9976) for endometrial dating and is being applied in clinical settings to establish accurately the timing of receptivity in individual women, enabling replacement of a blastocyst at an optimal time.

24. Kurihara I, Lee DK, Petit FG, Jeong J, Lee K, Lydon JP, et al. COUP-TFII mediates progesterone regulation of uterine implantation by controlling ER activity. PLoS Genet. 2007;3(6):e102. 0030102. 25. Williams KC, Renthal NE, Condon JC, Gerard RD, Mendelson CR. MicroRNA-200a serves a key role in the decline of progesterone receptor function leading to term and preterm labor. Proc Natl Acad Sci U S A. 2012;109(19):7529–34. 1200650109. 26. Ma WG, Song H, Das SK, Paria BC, Dey SK. Estrogen is a critical determinant that specifies the duration of the window of uterine receptivity for implantation.

Progesterone receptor requires a co-chaperone for signalling in uterine biology and implantation. Reprod Biomed Online. 2007;14(Spec No 1):39–48. 1016/S1472-6483(10)61457-5. 22. Matsumoto H, Zhao X, Das SK, Hogan BL, Dey SK. Indian hedgehog as a progesteroneresponsive factor mediating epithelial-mesenchymal interactions in the mouse uterus. Dev Biol. 2002;245(2):280–90. 0645. 23. Lee K, Jeong J, Kwak I, Yu CT, Lanske B, Soegiarto DW, et al. Indian hedgehog is a major mediator of progesterone signaling in the mouse uterus.

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