Yen & Jaffe's Reproductive Endocrinology: Expert Consult 6th by Jerome F. Strauss III MD PhD, Robert L. Barbieri MD

By Jerome F. Strauss III MD PhD, Robert L. Barbieri MD

Completely revised and now more suitable with colour art, the recent variation of this optimal reference keeps to supply the newest info at the analysis and administration of reproductive endocrine problems. nationwide and overseas leaders from the sector of reproductive endocrinology-including 30 new authors-equip you with insurance that encompasses the total spectrum of reproductive pathophysiology and issues, from being pregnant and beginning to reproductive getting older. Full-color illustrations and new drawings offer a real-life depiction of simple telephone constructions and endocrine responses for a greater figuring out of the fabric, whereas new chapters discover the problems shaping present day perform. As knowledgeable seek advice identify, it contains handy on-line entry to the whole textual content of the book-fully searchable-along with the entire photos, and references associated with Medline at the complete spectrum of reproductive pathophysiology and problems, from being pregnant and beginning to reproductive getting older. comprises the paintings of leaders within the box of reproductive endocrinology for suggestions you could trust.Features every time, at any place on-line entry to the full textual content of the book-fully searchable-as good as all the pictures, and references associated with Medline.Offers new content material on maintenance of fertility, endocrine disturbances affecting copy, imaging applied sciences, and adolescent reproductive endocrinology that discover the problems shaping modern practice.Includes full-color illustrations and new drawings which offer a real-life depiction of anatomy and phone functionality and disorder for a better understanding.Provides a listing of advised readings on the finish of every bankruptcy for extra reference. provides clean insights into brand new box and destiny advances, in addition to a better foreign viewpoint.

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This observation suggests that alternative surge mechanisms exist in animals that chronically lack a functional kisspeptin signaling system. Figure 1-15 summarizes the model for kisspeptin/ KISS1R-mediated negative and positive feedback regulation of GnRH/LH in female rodents. In the male and during most of the estrous cycle in females, gonadal steroid feedback inhibits the activity of Kiss1 neurons in the ARC, maintaining the proper basal gonadotropin stimulation of SCN AVPV + + Kiss I neuron Positive feedback GnRH neuron + + + Negative feedback + Kiss I neuron ?

These include the vomeronasal organ, the medial amygdala, the bed nucleus of the stria terminalis, the AVPV, the SON, the SCN, the locus ceruleus, and the spinal nucleus of the bulbocavernosus (in the spinal cord). There is less consensus on which and to what degree various structures in the ­human brain are sexually differentiated. In 1982, DelacosteUtamsing and Holloway reported that a portion of the corpus callosum, the splenium, is more bulbous in men than in women,207 although this finding has been controversial.

CRH-­expressing neurons are found in the parvicellular region of the PVN, which receives and processes information about metabolism, fuel status, and sympathetic tone. CRH (administered intracerebroventricularly) acts as a catabolic molecule, decreasing feeding and reducing body weight. Leptin and other metabolic hormones stimulate CRH secretion, which is believed to mediate at least part of the inhibitory effects of leptin on feeding behavior and body weight. 200 However, the fasting-­induced inhibition of gonadotropin secretion persists in the CRH knockout, which would imply that other factors besides CRH play a critical role in mediating the effects of metabolic stress on the ­reproductive axis.

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